L-Tryptophan | 73-22-3

I-Tryptophan (i-IUPAC-IUBMB isifinyezo: Trp noma W; IUPAC isifinyezo: L-Trp noma D-Trp; edayiselwa ukusetshenziswa kwezokwelapha njenge-Tryptan) ingenye yama-amino acid angama-22 ajwayelekile kanye ne-amino acid ebalulekile ekudleni komuntu, njengoba kuboniswa ukukhula kwayo. imiphumela kumagundane. Ifakwe ikhodi kukhodi yofuzo evamile njenge-codon UGG. I-L-stereoisomer ye-tryptophan kuphela esetshenziswa amaprotheni okufundisa noma ama-enzyme, kodwa i-R -stereoisomer iyatholakala ngezikhathi ezithile.unama-peptide akhiqizwa ngokwemvelo (ngokwesibonelo, i-marine venom peptide contryphan).Isici esihlukanisayo sesakhiwo se-tryptophan ukuthi iqukethe iqembu elisebenzayo le-indole.

Kunobufakazi bokuthi amazinga e-tryptophan egazi angeke aguqulwe ngokushintsha ukudla, kodwa isikhathi esithile, i-tryptophan ibilokhu itholakala ezitolo zokudla zezempilo njengesengezo sokudla.

Ucwaningo lwezokwelapha lubonise imiphumela exubile ngokuphathelene nokusebenza kwe-tryptophan njengosizo lokulala, ikakhulukazi ezigulini ezivamile. I-Tryptophan ibonise ukusebenza kahle okuthile ekwelapheni ezinye izimo ezihlukahlukene ngokuvamile ezihlotshaniswa namazinga aphansi e-serotonin ebuchosheni. Ikakhulukazi, i-tryptophan ibonise isithembiso njenge-antidepressant iyodwa futhi "njenge-augmenter" yezidakamizwa ezidambisa ukucindezeleka. Kodwa-ke, ukwethembeka kwalezi zivivinyo zomtholampilo kuye kwabatshazwa ngenxa yokuntuleka kokulawula okusemthethweni nokuphindaphinda. Ngaphezu kwalokho, i-tryptophan ngokwayo ingase ingabi wusizo ekwelapheni ukudangala noma ezinye izimo ezincike ku-serotonin, kodwa ingase ibe usizo ekuqondeni izindlela zamakhemikhali ezizonikeza izikhombisi-ndlela zocwaningo ezintsha zemithi.