Adenosine | 58-61-7

I-Adenosine, i-nucleoside eyakhiwe i-adenine ne-ribose, inezinhlelo zokusebenza ezimbalwa ezibalulekile kwezokwelapha kanye ne-physiology ngenxa yemiphumela yayo yomzimba ezinhlelweni ezihlukahlukene emzimbeni.

Umuthi Wenhliziyo:

Ithuluzi Lokuxilonga: I-Adenosine isetshenziswa njenge-agent yokucindezeleka kwemithi ngesikhathi sokuhlolwa kokucindezeleka kwenhliziyo, njenge-imaging ye-myocardial perfusion. Kuyasiza ukuhlola isifo se-coronary artery ngokufaka i-coronary vasodilation, ukulingisa imiphumela yokuzivocavoca umzimba.

Ukwelashwa kwe-Supraventricular Tachycardia (SVT): I-Adenosine imithi yokuqala yokuqeda iziqephu ze-SVT. Isebenza ngokunciphisa ukuqhutshwa kwe-atrioventricular node, iphazamisa izindlela eziphinde zingene ezinesibopho se-SVT.

I-Neurology:

Ukulawula Ukubanjwa: I-Adenosine iyi-anticonvulsant engapheli ebuchosheni. Ukushintsha ama-adenosine receptors kungase kube nemiphumela ye-antiepileptic, futhi ama-adenosine-release agents ayaphenywa njengezindlela zokwelapha ezingase zibe khona zesithuthwane.

I-Neuroprotection: I-Adenosine receptors idlala indima ekuvikeleni ama-neurons ekulimaleni kwe-ischemic kanye nokucindezeleka okwenziwe nge-oxidative. Ucwaningo luhlola amandla e-adenosine njenge-ejenti ye-neuroprotective ku-stroke kanye nezifo ze-neurodegenerative njenge-Parkinson kanye ne-Alzheimer's.

Umuthi Wokuphefumula:

I-Bronchodilation: I-Adenosine isebenza njenge-bronchodilator futhi isetshenziselwa ukuhlolwa kwe-bronchoprovocation ukuze kuhlolwe isifuba somoya. Idala i-bronchoconstriction kubantu abanesifuba somoya, esiza ekuboneni i-hyperreactivity yomgwaqo.

Izici ze-Antiarrhythmic:

I-Adenosine ingacindezela izinhlobo ezithile ze-arrhythmias ngokushintsha umsebenzi kagesi enhliziyweni, ikakhulukazi ku-atria kanye ne-atrioventricular node. Ingxenye yempilo yayo emfushane ikhawulela imiphumela yesistimu.

Ithuluzi lokucwaninga:

I-Adenosine nama-analogues ayo asetshenziswa kabanzi ocwaningweni ukutadisha indima yama-adenosine receptors ezinqubweni ezehlukene ze-physiological and pathological. Basiza ukucacisa imisebenzi ye-adenosine ku-neurotransmission, ukuphendula kwamasosha omzimba, ukuvuvukala, nokulawulwa kwenhliziyo.

Izinhlelo zokusebenza ezingaba zokwelapha:

Izidakamizwa ezisekelwe ku-adenosine ziyaphenywa ukuze zisetshenziswe ezimweni ezinjengomdlavuza, ukulimala kwe-ischemic, ukuphathwa kwezinhlungu, kanye nokuphazamiseka kokuvuvukala. I-Adenosine receptor agonists kanye nabaphikisi baphakathi kwezinhlanganisela ezisacwaningwayo.