Tacrolimus |104987-11-3

I-Tacrolimus, eyaziwa nangokuthi igama layo lokuhweba i-Prograf phakathi kwezinye, isidakamizwa esinamandla sokuzivikela komzimba esisetshenziswa ngokuyinhloko ekufakeni isitho somzimba ukuvimbela ukwenqatshwa.

Indlela Yesenzo: I-Tacrolimus isebenza ngokuvimbela i-calcineurin, i-protein phosphatase edlala indima ebalulekile ekusebenziseni ama-T-lymphocyte, okungamangqamuzana omzimba omzimba abandakanyeka ekwenqatshweni kwegraft.Ngokuvimbela i-calcineurin, i-tacrolimus ivimba ukukhiqizwa kwama-cytokines ane-pro-inflammatory futhi ivimbele ukusebenza kwama-T-cell, ngaleyo ndlela icindezele impendulo yokuzivikela komzimba ngokumelene nesitho esitshaliwe.

Izinkomba: I-Tacrolimus ikhonjiswe ukuvimbela ukwenqatshwa kwesitho ezigulini ezithola ukufakelwa kwesibindi, izinso, noma inhliziyo.Ivamise ukusetshenziswa ngokuhlanganiswa namanye ama-immunosuppressive agents afana ne-corticosteroids ne-mycophenolate mofetil.

Ukuphatha: I-Tacrolimus ivamise ukuphathwa ngomlomo ngendlela yama-capsules noma isixazululo somlomo.Ingase futhi inikezwe ngomthambo ezimweni ezithile zomtholampilo, njengasesikhathini esisheshayo sangemva kokufakelwa.

Ukuqapha: Ngenxa yenkomba yayo yokwelapha emincane kanye nokuhlukahluka kokumuncwa, i-tacrolimus idinga ukuqapha ngokucophelela amazinga egazi ukuze kuqinisekiswe ukusebenza ngempumelelo kokwelapha kuyilapho kunciphisa ubungozi bobuthi.Ukuqapha izidakamizwa zokwelashwa kuhilela ukukalwa njalo kwamazinga egazi e-tacrolimus kanye nokulungiswa komthamo ngokusekelwe kulawa mazinga.

Imiphumela Emibi: Imiphumela emibi evamile ye-tacrolimus ihlanganisa i-nephrotoxicity, neurotoxicity, umfutho wegazi ophakeme, i-hyperglycemia, ukuphazamiseka emathunjini, kanye nokungenwa kalula kwezifo.Ukusetshenziswa isikhathi eside kwe-tacrolimus kungase kwandise ingozi yokuthuthukisa izifo ezithile, ikakhulukazi umdlavuza wesikhumba kanye ne-lymphoma.

Ukusebenzisana Kwezidakamizwa: I-Tacrolimus yenziwa i-metabolized ngokuyinhloko yi-cytochrome P450 enzyme system, ikakhulukazi i-CYP3A4 ne-CYP3A5.Ngakho-ke, izidakamizwa eziheha noma ezivimba lawa ma-enzyme zingathinta amazinga e-tacrolimus emzimbeni, okungase kuholele ekwehlulekeni kokwelapha noma ubuthi.

Ukucatshangelwa Okukhethekile: Umthamo we-Tacrolimus udinga umuntu ngamunye ngokusekelwe ezicini ezifana neminyaka yesiguli, isisindo somzimba, ukusebenza kwezinso, imithi ehambisanayo, nokuba khona kwezifo ezihambisanayo.Ukuqapha eduze nokulandelela njalo nabahlinzeki bezempilo kubalulekile ukuze kuthuthukiswe ukwelashwa nokunciphisa imiphumela emibi.