Fludarabine | 21679-14-1

I-Fludarabine umuthi we-chemotherapy osetshenziswa kakhulu ekwelapheni izinhlobo ezithile zomdlavuza, ikakhulukazi izifo ze-hematological. Nakhu ukubuka konke:

I-Mechanism of Action: I-Fludarabine iyi-analog ye-nucleoside ephazamisa ukuhlanganiswa kwe-DNA ne-RNA. Ivimbela i-DNA polymerase, i-DNA primase, nama-enzyme e-DNA ligase, okuholela ekuqhekekeni kwe-DNA strand kanye nokuvinjelwa kwezinqubo zokulungisa i-DNA. Lokhu kuphazamiseka kokuhlanganiswa kwe-DNA kugcina kudala i-apoptosis (i-programmed cell death) kumaseli ahlukana ngokushesha, okuhlanganisa namaseli omdlavuza.

Izinkomba: I-Fludarabine ijwayele ukusetshenziswa ekwelapheni i-lymphocytic leukemia (CLL), kanye nezinye izifo ze-hematological ezifana ne-indolent non-Hodgkin lymphoma kanye ne-mantle cell lymphoma. Ingase futhi isetshenziswe ezimweni ezithile ze-acute myeloid leukemia (AML).

Ukuphatha: I-Fludarabine ivamise ukulawulwa nge-intravenously (IV) esimweni somtholampilo, nakuba ingase futhi inikezwe ngomlomo kwezinye izimo. Umthamo kanye nohlelo lokuphatha luncike kumdlavuza othile owelashwayo, kanye nempilo yesiguli iyonke kanye nendlela esisabela ngayo ekwelashweni.

Imiphumela Emibi: Imiphumela emibi evamile ye-fludarabine ihlanganisa ukucindezelwa komnkantsha (okuholela ku-neutropenia, i-anemia, ne-thrombocytopenia), isicanucanu, ukuhlanza, isifo sohudo, imfiva, ukukhathala, nokwanda kokungenwa yizifo. Kungase futhi kubangele imiphumela emibi kakhulu efana ne-neurotoxicity, i-hepatotoxicity, kanye nobuthi be-pulmonary kwezinye izimo.

Izinyathelo zokuqapha: I-Fludarabine iphikisiwe ezigulini ezinokucindezelwa okukhulu komnkantsha noma ukungasebenzi kahle kwezinso. Kufanele isetshenziswe ngokuqapha ezigulini ezinesifo sesibindi esivele sikhona noma sezinso, kanye nakwabesifazane abakhulelwe noma abancelisa ngenxa yamandla okulimaza umbungu noma usana.

Ukusebenzisana Kwezidakamizwa: I-Fludarabine ingase ihlanganyele neminye imithi, ikakhulukazi leyo ethinta umsebenzi womnkantsha wamathambo noma umsebenzi wezinso. Kubalulekile ukuthi abahlinzeki bezempilo babuyekeze uhlu lwemithi yesiguli ngokucophelela futhi baqaphe ukusebenzisana kwezidakamizwa okungase kube khona.

Ukuqapha: Ukuqapha njalo ukubala kwegazi nokusebenza kwezinso kubalulekile ngesikhathi sokwelashwa nge-fludarabine ukuze kuhlolwe izimpawu zokucindezelwa komnkantsha noma eminye imiphumela emibi. Ukulungiswa komthamo kungase kudingeke ngokusekelwe kulawa mapharamitha wokuqapha.