I-Huperzine A ｜120786-18-7

I-Huperzine A iyisithuthukisi sokuqonda esivimbela ama-enzyme alulaza i-neurotransmitter acetylcholine yokufunda.Kungokwesigaba se-cholinergic sama-molecule angasiza ukulwa nokuncipha kwengqondo kubantu asebekhulile.

I-Huperzine A iyinhlanganisela ekhishwe emndenini we-huperzine.Ibizwa ngokuthi i-acetylcholinesterase inhibitor, okusho ukuthi ivimbela i-enzyme ekuphuleni i-acetylcholine, okuholela ekwandeni kwe-acetylcholine.

I-acetylcholine ibizwa ngokuthi i-neurotransmitter yokufunda futhi ibandakanyeka ekufinyezweni kwemisipha.

I-Huperzine A ibonakala iyinhlanganisela ephephile uma kuqhathaniswa.Ubuthi kanye nezifundo zabantu ezivela ezifundweni zezilwane azizange zibonise imiphumela emibi emithini evamile yokwengeza.I-Huperzine A nayo iyasetshenziswa ekuhlolweni kokuqala ukuvimbela isifo i-Alzheimer's.

I-Huperzine A ivela ku-cerebrospinal fluid futhi yeqa kalula umgoqo wegazi nobuchopho.

I-Huperzine A yaziwa kakhulu njenge-acetylcholinesterase inhibitor.Ikakhulukazi, ivimbela i-G4 subtype ye-acetylcholinesterase, evamile ebuchosheni bezilwane ezincelisayo.Isebenza kangcono noma isebenze ngokulinganayo ngokumelene nezinye i-acetylcholinesterase inhibitors, njenge-tacillin noma i-rivastatin.Njenge-inhibitor, inobudlelwane obuphezulu be-acetylcholinesterase.Ngesikhathi esifanayo, ine-dissociation engaguquki kancane, okwenza uhhafu wempilo ibe yinde kakhulu.

Ngaphezu kokuvimbela i-acetylcholinesterase, ingabuye ibonakale njenge-neuroprotective ngokumelene ne-glutamate, i-beta amyloid pigmentation, kanye nobuthi obubangelwa i-H2O2.

I-Huperzine A ingakhuthaza ukwanda kwamaseli e-hippocampal neural stem cells (NSCs).Kubonakala kukhuthaza ukukhula kwezinzwa ngemithamo ehlobene ne-biorelated.