L-Carnitine |541-15-1
Incazelo Yemikhiqizo
I-L-carnitine, ngezinye izikhathi ebizwa ngokuthi i-carnitine nje, iwumsoco owenziwe ku-amino acids methionine ne-lysine esibindi nezinso futhi ugcinwe ebuchosheni, enhliziyweni, ezicubu zemisipha, nesidoda.Abantu abaningi bakhiqiza inani elanele lalesi sakhi ukuze bahlale bephilile.Kodwa-ke, izifo ezithile zezokwelapha zingavimbela i-carnitine biosynthesis noma zivimbele ukusatshalaliswa kwayo kumaseli wezicubu, njenge-claudication ephakathi, isifo senhliziyo, kanye nokuphazamiseka okuthile kofuzo.Eminye imithi ingase futhi ithinte kabi i-carnitine metabolism emzimbeni.Umsebenzi oyinhloko we-L-carnitine ukuguqula i-lipids, noma amafutha, abe nguphethiloli wamandla.
Ngokukhethekile, indima yayo ukuhambisa ama-fatty acids ku-mitochondria yamaseli e-eukaryotic ahlala ngaphakathi kolwelwesi oluvikelayo oluzungeza amangqamuzana.Lapha, ama-fatty acids angena kwi-beta oxidation futhi ahlehle akheke i-acetate.Lesi senzakalo yiso esiqala umjikelezo we-Krebs, uchungechunge lwezinqubo eziyinkimbinkimbi zezinto eziphilayo ezibalulekile ukuze kunikezwe amandla kuwo wonke amangqamuzana emzimbeni.L-carnitine nayo idlala indima ekulondolozeni amathambo.Ngeshwa, lesi sakhi sincipha kancane emathanjeni kanye ne-osteocalcin, iphrotheni ekhishwa ama-osteoblasts ebandakanyeka ekwakhiweni kwamathambo.Eqinisweni, lokhu kusilela yizici eziyinhloko ezibangela i-osteoporosis kwabesifazane abangemva kokuya esikhathini.Ucwaningo luye lwabonisa ukuthi lesi simo singahlehliswa nge-L-carnitine supplementation, okwandisa amazinga atholakalayo e-osteocalcin.
Ezinye izinkinga ezingase zibhekane nokwelashwa kwe-L-carnitine zihlanganisa ukusetshenziswa okuthuthukisiwe kwe-glucose kubantu abanesifo sikashukela, izimpawu ezincishisiwe ezihlobene nesifo sokukhathala okungapheli, nokulawulwa kwe-thyroid okuthuthukisiwe kubantu abane-hyperthyroidism.Kukhona nobufakazi bokuthi i-propionyl-L-carnitine ingasiza ekuthuthukiseni ukungasebenzi kahle kwe-erectile emadodeni, kanye nokuthuthukisa ukusebenza kahle kwe-sidenafil, imithi ethengiswa ngaphansi kophawu lokuthengisa i-Viagra.Ngaphezu kwalokho, ucwaningo luye lwabonisa ukuthi lesi sakhi sithuthukisa inani lesidoda kanye ne-motility.
Ukucaciswa
| IZINTO | Imininingwane |
| Ukubukeka | Amakristalu amhlophe noma i-crystalline powder |
| Ukuhlonza | Indlela Yekhemikhali noma i-IR noma i-HPLC |
| Ukubukeka Kwesixazululo | Icacile futhi Ayinambala |
| Ukuzungezisa okuqondile | -29°∼-32° |
| PH | 5.5-9.5 |
| Okuqukethwe Amanzi =< % | 1 |
| Isivivinyo % | 97.0∼103.0 |
| Izinsalela Ekuthutheni =<% | 0.1 |
| I-Ethanol esele =<% | 0.5 |
| Izinsimbi Ezisindayo =< PPM | 10 |
| I-Arsenic = <PPM | 1 |
| I-Chloride =<% | 0.4 |
| Ukuhola =< PPM | 3 |
| I-Mercury =< PPM | 0.1 |
| I-Cadmium =<PPM | 1 |
| Inani Lepuleti Eliphelele = | 1000cfu/g |
| Imvubelo & Isikhunta = | 100cfu/g |
| E. Coli | Okubi |
| I-Salmonella | Okubi |
