L-Tyrosine |60-18-4

I-Tyrosine (efushanisiwe ngokuthi i-Tyr noma i-Y) noma i-4-hydroxyphenylalanine, ingenye yama-amino acid angu-22 asetshenziswa amaseli ukuze ahlanganise amaprotheni.Ihlanganisa i-UAC ne-UAU.Kuyi-amino acid engabalulekile eneqembu le-polar side.Igama elithi "tyrosine" lisuselwa kwelesiGreki elithi tyros, okusho ushizi, njengoba latholwa okokuqala ngo-1846 ngusokhemisi waseJalimane uJustus von Liebig ku-proteincasein evela kushizi.Ibizwa ngokuthi i-tyrosyl uma ibizwa ngokuthi i-groupor side chain.yrosine iyisandulela sama-neurotransmitters futhi inyusa amazinga e-plasmaneurotransmitter (ikakhulukazi i-DOPAM ne-norepinephrine) kodwa iyancipha uma kukhona umthelela kumizwa.Umphumela wesimo sengqondo ubonakala kakhulu kubantu abangaphansi kwezimo ezicindezelayo.
Ngaphandle kokuba yi-proteinogenic aminoacid, i-tyrosine inendima ekhethekile ngenxa yokusebenza kwe-phenol.Ivela kumaprotheni ayingxenye yezinqubo zokudlulisa isignali.Isebenza njengesamukeli samaqembu e-phosphate adluliswa ngendlela yama-proteinkinase (okubizwa ngokuthi i-receptor tyrosine kinases).I-phosphorylation ye-hydroxylgroup ishintsha umsebenzi wephrotheni eqondiwe.
Izinsalela ze-tyrosine nazo zidlala indima ebalulekile ku-photosynthesis.Kuma-chloroplast (i-photosystem II), isebenza njengomnikeli we-anelectron ekunciphiseni i-chlorophyll ene-oxidized.Kule nqubo, idlula i-deprotonation yeqembu layo le-phenolic OH.Le radical kamuva yehliswa ku-photosystem II ngamaqoqo amane ayisisekelo e-manganese.
Ucwaningo oluningi luye lwathola ukuthi i-tyrosine ingaba wusizo ezimweni zokucindezeleka, amakhaza, ukukhathala, ukulahlekelwa othandekayo njengokufa noma isehlukaniso, umsebenzi omude nokuntula ubuthongo, ngokunciphisa amazinga e-hormone yokucindezeleka, ukunciphisa ukulahlekelwa kwesisindo okubangelwa ukucindezeleka okubonakalayo. ukuhlolwa kwezilwane, ukuthuthukiswa kokusebenza kwengqondo nokusebenza ngokomzimba okubonwa ekuhlolweni kwabantu;kodwa-ke, ngenxa yokuthi i-tyrosine hydroxylase iyi-enzyme enciphisa izinga, imiphumela ayibalulekile kakhulu kunaleyo ye-L-DOPA.
I-Tyrosine ibonakala ingenawo umthelela obalulekile kumizwa, ingqondo noma ukusebenza komzimba ezimweni ezivamile.Umthamo wansuku zonke wokuhlolwa komtholampilo osekelwa ezincwadini cishe u-100 mg/kg kumuntu omdala, okulingana namagremu angu-6.8 ku-150 lbs.Umthamo ojwayelekile ufinyelela ku-500-1500 mg ngosuku (umthamo ophakanyiswa abakhiqizi abaningi; imvamisa ukulingana namakhepsuli angu-1-3 we-tyrosine emsulwa).Akunconyelwe ukweqa i-12000 mg (12 g) ngosuku.