Uridine | 58-96-8

I-Uridine iyi-nucleoside ye-pyrimidine esebenza njengesisekelo sokwakha i-RNA (i-ribonucleic acid), enye yezinhlobo ezimbili ezinkulu zama-nucleic acid ezibalulekile ekugcinweni nasekudlulisweni kolwazi lofuzo kumaseli.

Isakhiwo Sekhemikhali: I-Uridine iqukethe i-pyrimidine base uracil exhunywe ku-ribose enekhabhoni kashukela emihlanu ngebhondi ye-β-N1-glycosidic.

Indima Yebhayoloji:

I-RNA Building Block: I-Uridine iyingxenye ebalulekile ye-RNA, lapho yakha khona umgogodla wama-molecule e-RNA eceleni kwamanye ama-nucleosides njenge-adenosine, i-guanosine, ne-cytidine.

I-Messenger RNA (mRNA): Ku-mRNA, izinsalela ze-uridine zifaka imininingwane yofuzo ngesikhathi sokuloba, ziphethe imiyalelo esuka ku-DNA iye emshinini wokwenziwa kwamaprotheni kuseli.

I-Dlulisa i-RNA (tRNA): I-Uridine iphinde ibe khona nama-molecule e-intRNA, lapho ibamba iqhaza enqubweni yokuhumusha ngokubona ama-codon athile kanye nokuletha ama-amino acid ahambisanayo ku-ribosome.

I-Metabolism: I-Uridine ingahlanganiswa de novo ngaphakathi kwamaseli noma itholakale emithonjeni yokudla. Ikhiqizwa ngokuguqulwa kwe-enzymatic kwe-orotidine monophosphate (OMP) noma i-uridine monophosphate (UMP) endleleni ye-pyrimidine biosynthesis.

Ukubaluleka Kokuphila:

I-Neurotransmitter Precursor: I-Uridine idlala indima ekusebenzeni kobuchopho nasekuthuthukisweni. Kuyisandulela sokuhlanganiswa kwe-phospholipids yobuchopho, okuhlanganisa i-phosphatidylcholine, ebalulekile ku-neuronal membrane ubuqotho kanye nokusayina kwe-neurotransmitter.

I-Neuroprotective Effects: I-Uridine iye yafundelwa izici zayo ezingase zibe yi-neuroprotective kanye nekhono layo lokuthuthukisa umsebenzi we-synaptic kanye ne-neuronal plasticity.

Amandla Okwelapha:

I-Uridine kanye nokuphuma kwayo kuye kwaphenywa ukuze kusetshenziswe izindlela zokwelapha ezingase zibe khona ezinkingeni zemizwa, okuhlanganisa nesifo i-Alzheimer's kanye nokuphazamiseka kwemizwa.

Ukwengezwa kwe-uridine kuye kwahlolisiswa njengesu lokusekela ukusebenza kwengqondo nokunciphisa izimpawu ezihlobene nezifo ze-neurodeergenerative.

Imithombo Yokudla: I-Uridine itholakala ngokwemvelo ekudleni okuhlukahlukene, okuhlanganisa inyama, inhlanzi, imifino, kanye nemikhiqizo yobisi.