I-Conotoxin |129129-65-3

Ama-conotoxins yiqembu elihlukahlukene lobuthi be-peptide obuncane obukhiqizwa iminenke ye-cone (uhlobo lwe-Conus).Leminenke yasolwandle itholakala olwandle olushisayo nolwandle olushisayo futhi yaziwa ngendlela yayo yokuzingela eyingqayizivele.Iminenke ye-cone isebenzisa ubuthi ukuze ivimbe inyamazane yayo, ehlanganisa ngokuyinhloko ezinye izinto eziphilayo zasolwandle njengezinhlanzi nezikelemu.

Ama-conotoxin atholakala ebuhlungwini beminenke ye-cone futhi enza izinjongo ezihlukahlukene, njengokunqoba inyamazane nokuzivikela ezilwaneni ezidla ezinye.Ama-peptide aku-conotoxins anemisebenzi eminingi eminingi yemithi futhi angasebenzisana nama-receptors athile kanye neziteshi ze-ion ohlelweni lwezinzwa.Ngenxa yokucaciswa kwawo okuphezulu kokuhlosiwe okuthile, ama-conotoxin adonse ukunaka kubacwaningi ngokusetshenziswa kwawo okungenzeka kwezokwelapha nasekuthuthukisweni kwezidakamizwa.

Ama-conotoxins ahlukaniswa abe imindeni eminingana ngokuya ngesakhiwo sawo kanye nama-receptors okuhlosiwe asebenzisana nawo.Eminye imindeni ihlanganisa:

I-A-conotoxins: Khomba ama-nicotinic acetylcholine receptors.

I-M-conotoxins: Vimba iziteshi zesodium ezine-voltage-gated.

Ama-O-conotoxins: Hlangana namashaneli e-calcium ane-voltage-gated.

I-T-conotoxins: Iziteshi ze-potassium eziqondiswe ku-voltage-gated.

Lobu buthi bubonise isithembiso ekwakhiweni kwemithi emisha yokulawula ubuhlungu, ukuphazamiseka kwemizwa, nezinye izimo zezokwelapha.Ososayensi banentshisekelo ikakhulukazi ekhonweni labo lokukhetha ngokukhetha ama-receptors athile, okuwenza abe namandla ekwakhiweni kwemithi eqondiswe kakhulu nesebenza ngempumelelo.

Iphakheji:25KG/BAG noma njengoba ucela.

Isitoreji:Gcina endaweni engenawo umoya, neyomile.

IsikhuluOkujwayelekile:Izinga lamazwe ngamazwe.